Flavanones are polyphenols found in citrus fruits (lemons, grapefruits and oranges). They are so bioavailable that they can appear in blood plasma as soon as 20 minutes after ingestion, though their concentrations aren’t maximized until after about four hours. This makes flavanones a significant contributor to the antioxidant pool that circulates in your blood. However, since these flavanones are completely excreted after 24 hours, it’s beneficial to consume foods that contain them, such as citrus fruits, on a daily basis. Antioxidants help our body repair cells damaged by free radicals. The most common antioxidants are beta-carotene, lycopene and vitamins A, C and E. Antioxidants can also be found in fruits, vegetables and teas. Flavanone has been used widely for their antimicrobial and antifungal property. We synthesized 1-[2-(furan-2-yl)-2,3-dihydrochromen-4-ylidene]-4-phenylsemi-carbazone (Y2i). The derivative was characterized by Physico-chemical (TLC and Melting Point) and spectral analysis (I.R., N.M.R and Mass Spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant activity, tail immersion method for analgesic activity and paw edema method for anti-inflammatory activity respectively and compared with the standard drug diazepam and diclofenac sodium. Compound Y2i (2-(furan-2-yl) OR (o-furfuryl) substitution was found to have more significant results as comparable to standard drug diazepam and diclofenac sodium respectively. The title compound was also screened for in-vitro antimicrobial activity by cup-plate method and compound Y2i was found to have significant results against all the bacterial strains and the fungal strain as compared with streptomycin and fluconazole.
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